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Cardiac gap junctions physiology, regulation, pathophysiology, and pharmacology by S. Dhein

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Published by Karger in Basel, New York .
Written in English


  • Heart conduction system.,
  • Gap junctions (Cell biology),
  • Arrhythmia.,
  • Heart -- physiology.,
  • Gap Junctions -- physiology.,
  • Gap Junctions -- drug effects.,
  • Heart Diseases -- physiopathology.

Book details:

Edition Notes

Includes bibliographical references (p. 121-139) and index.

StatementS. Dhein.
LC ClassificationsQP114.C65 D48 1998
The Physical Object
Paginationxi, 148 p. :
Number of Pages148
ID Numbers
Open LibraryOL700685M
ISBN 103805565674
LC Control Number97048990

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Cardiac gap junction channel activity has been recorded in two neonatal mammalian preparations, rat and hamster ventricular myocyte pairs. With the cloning of a gap junction protein in adult rat heart, it is of interest to know if other mammalian cardiac gap junctions possess similar functional properties and, presumably, the same protein Author: Richard D. Veenstra. Much of the basic science that concerns the role of gap junctions in arrhythmias has been reviewed in other chapters in this book. The purpose of this chapter is to create an intellectual framework for the clinician that is based on biophysical theory and to allow the researcher who is not a physician insight into clinical thought by: 3. Gap Junctions (Cell-to-Cell Conduction) In the heart, cardiac muscle cells (myocytes) are connected end to end by structures known as intercalated disks. These are irregular transverse thickenings of the sarcolemma, within which there are desmosomes that hold the cells together and to which the myofibrils are attached. The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target. Hoagland DT(1), Santos W(2), Poelzing S(3), Gourdie RG(4). Author information: (1)Virginia Tech Carilion Research Institute, Roanoke, VA, USA. (2)Department of Chemistry, Blacksburg, VA, USA.

Adherens junctions, gap junctions, and desmosomes are intercalated discs that connect cardiac muscle cells. Gap junctions specifically allow for the transmission of action potentials within cells.   Gap junctions are part of the intercalated discs. When one cardiac muscle cell is stimulated to contract, a gap junction transfers the stimulation to the next cardiac cell. Cardiac muscles are interconnected by gap junctions –the heart beat is All –or –None, and spreads. 5. Cardiac muscles excites itself. Normally skeletal muscles will contract only if it receives a nerve impulse. Nerves that carry impulses to the heart influence the rate and strength of contraction, . Gap junctions are membrane channels that mediate the cell-to-cell movement of ions and small metabolites. In the heart, gap junctions play an important role in impulse conduction. Studies over the last decade have revealed that gap junctions are encoded by a .

In recent years, gap junction research in the cardiovascular system has considerably improved the understanding of cardiac function and the vasculature in health and disease. The present book focuses on the communication of intercellular gap junctions in the cardiovascular system but also includes aspects of physiology, medicine and cell biology. Nonetheless, research at the conjunction of cardiac development and gap junctions is a diverse and fast-moving arena. Significant recent advances have resulted from mutational analysis or transgenic alterations of the genes encoding the subunits which comprise the gap junction channel-the connexin proteins (). Such work has directly linked. Cardiac arrhythmogenesis and the gap junction. Cardiac arrhythmogenesis and the gap junction J Mol Cell Cardiol. Jan;27(1) doi: /s(08) Authors N S Peters 1, C R Green, P A Poole-Wilson, N J Severs. Affiliation 1 Department of Cardiac Medicine.   Time for primary review 27 days. Gap junctions are clusters of closely packed channels (Fig. 1A and B) that directly connect the cytoplasmic compartments of neighbouring cells and allow the passage of ions and small molecules (gap junction channel 1 hemichannel or connexon is contributed by each of the two cardiomyocytes ().Connexons are formed by Cited by: